Ionis Pharmaceuticals Inc.

IONS·NASDAQ·$76.07Share Price as of 11/2·$13BMarket Cap as of 11/2

Financials

10-QQ2 ended 06/30/2607/29/26 10-QQ1 ended 03/31/2604/29/26 10-KFY 202502/26/26 10-QQ3 ended 09/30/2510/29/25 10-QQ2 ended 06/30/2507/30/25

Disclosures

8-KCurrent report10/23/26 8-KCurrent report10/21/26 8-KCurrent report09/23/26 8-KCurrent report09/04/26 8-KCurrent report09/04/26

Prospectuses and Registrations

S-8Registration of securities for employees07/31/26 S-8Registration of securities for employees07/30/25 424B5Prospectus supplement09/10/24 424B5Prospectus supplement09/09/24 S-8Registration of securities for employees08/05/24

Proxies

DEF 14ADefinitive proxy04/23/26 DEFA14AAdditional proxy materials04/23/26 DEF 14ADefinitive proxy04/25/25 DEFA14AAdditional proxy materials04/25/25 DEF 14ADefinitive proxy04/25/24

Ownership

Form 4Insider transaction10/19/26 Form 4Insider transaction10/19/26 144Proposed sale of securities10/16/26 Form 4Insider transaction09/02/26 Form 4Insider transaction09/02/26

Other

ARSAnnual report to shareholders04/23/26 ARSAnnual report to shareholders04/25/25 ARSAnnual report to shareholders04/25/24 ARSAnnual report to shareholders04/20/23 UPLOADLetter from the SEC01/26/21