Spruce Biosciences, Inc.

SPRB·NASDAQ·$51.81Share Price as of 11/2·$71MMarket Cap as of 11/2

Financials

10-QQ2 ended 06/30/2608/12/26 10-QQ1 ended 03/31/2605/13/26 10-KFY 202503/09/26 10-QQ3 ended 09/30/2511/10/25 10-QQ2 ended 06/30/2508/14/25

Disclosures

8-KCurrent report08/12/26 8-KCurrent report07/27/26 8-KCurrent report05/26/26 8-KCurrent report05/13/26 8-KCurrent report04/22/26

Prospectuses and Registrations

S-8Registration of securities for employees05/13/26 424B5Prospectus supplement04/21/26 424B5Prospectus supplement04/20/26 424B5Prospectus supplement03/09/26 S-8Registration of securities for employees03/09/26

Proxies

DEF 14ADefinitive proxy04/09/26 DEFA14AAdditional proxy materials04/09/26 DEFA14AAdditional proxy materials06/12/25 DEFA14AAdditional proxy materials06/06/25 DEFA14AAdditional proxy materials06/06/25

Ownership

SC 13GBeneficial ownership08/14/26 SC 13GBeneficial ownership08/14/26 SC 13G/ABeneficial ownership (amended)08/14/26 SC 13G/ABeneficial ownership (amended)08/14/26 SC 13G/ABeneficial ownership (amended)08/04/26

Other

ARSAnnual report to shareholders04/09/26 EFFECTRequest for effectiveness11/26/25 EFFECTRequest for effectiveness11/26/25 CORRESPCorrespondence with the SEC11/24/25 CORRESPCorrespondence with the SEC11/24/25