Spyre Therapeutics, Inc.

SYRE·NASDAQ·$73.65Share Price as of 11/2·$4BMarket Cap as of 11/2

Financials

10-QQ2 ended 06/30/2608/04/26 10-QQ1 ended 03/31/2605/05/26 10-KFY 202502/19/26 10-QQ3 ended 09/30/2511/04/25 10-QQ2 ended 06/30/2508/05/25

Disclosures

8-KCurrent report10/07/26 8-KCurrent report09/08/26 8-KCurrent report08/25/26 8-KCurrent report08/04/26 8-KCurrent report06/15/26

Prospectuses and Registrations

424B5Prospectus supplement10/06/26 424B5Prospectus supplement10/05/26 S-3ASRAutomatic shelf registration06/26/26 424B5Prospectus supplement04/16/26 424B5Prospectus supplement04/13/26

Proxies

DEF 14ADefinitive proxy04/10/26 DEFA14AAdditional proxy materials04/10/26 DEF 14ADefinitive proxy04/14/25 DEFA14AAdditional proxy materials04/14/25 DEF 14ADefinitive proxy04/01/24

Ownership

SC 13D/ABeneficial ownership (amended)10/09/26 Form 4Insider transaction10/02/26 Form 4Insider transaction10/02/26 Form 4Insider transaction10/02/26 144Proposed sale of securities10/01/26

Other

ARSAnnual report to shareholders04/10/26 EFFECTRequest for effectiveness03/04/26 EFFECTRequest for effectiveness02/27/26 CORRESPCorrespondence with the SEC02/25/26 UPLOADLetter from the SEC02/25/26